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LabVantage in the News 2004
National Cancer Institute Core Genotyping Center Goes Live with LabVantage Sapphire™ Life Science LIMS
Bridgewater, NJ March 1, 2004. LabVantage Sapphire™ Life Sciences LIMS used for high throughput genotyping analysis and evaluation of new technologies and innovations in genotype analysis.

LabVantage Solutions, Inc., a leading provider of Life Sciences LIMS and Enterprise LIMS solutions, announced today that the National Cancer Institute (NCI), the Federal government's principal agency for cancer research, and a component of the National Institutes of Health, is now live with LabVantage's Sapphire™ Life Sciences LIMS solution. The Core Genotyping Facility of the Intramural Program of the National Cancer Institute performs high-throughput genotyping and sequencing to support genetic analysis for a broad range of projects for NCI's Division of Cancer Epidemiology and Genetics (DCEG) and Center for Cancer Research (CCR). The Core Genotyping Facility is currently performing high throughput genetic analysis of over 25 different case-control and cohort based association studies, with as many as 75,000 separate samples expected to be analyzed. NCI's Core Genotyping Facility is using LabVantage Sapphire™ software to perform the high throughput genotyping analysis.

LabVantage Sapphire™ provides NCI with the ability to manage and track details of every sample from the DNA provider through the Core Genotyping Facility's functional laboratory units. It also provides the laboratory with capabilities for electronic worksheet generation, sample and genotype reagent tracking, and instrument and robotic integration. To increase operational efficiency, Sapphire™ is also used to track costs of all samples and genotypes processed. Prior to the implementation of LabVantage Sapphire™, there was no unified electronic system to coordinate the high throughput analysis. The implemented LIMS addresses critical issues in sample handling, SNP and assay validation, high throughput genotyping and quality control.

Sapphire™ addresses critical issues in sample handling, SNP and assay validation, high throughput genotyping and quality control, increasing efficiency and accuracy. The LIMS will enable the Core Genotyping Facility to discover, validate and provide more SNP genotype data to NCI investigators, more accurately and efficiently. Increased amounts of the highest quality SNP genotype data will further enable NCI investigators to translate hypotheses into findings with public health implications.

"The successful use of Sapphire™ at NCI's Core Genotyping Facility is a major achievement for LabVantage," said LabVantage Solutions President and CEO Jim Aurelio. "We are proud to be supporting NCI's cancer research projects and look forward to continuing our collaborative relationship."

LabVantage Sapphire™ Life Sciences LIMS. LabVantage Sapphire™ Informatics is a Life Sciences LIMS solution designed to help researchers integrate, automate, and manage business and Life-Sciences-related research processes to bring science to market faster. Sapphire™ connects multiple, dissimilar data sources into a logical, scalable, high-performance framework for scientific and business decision-making. Sapphire™ uses a browser-based interface to greatly simplify the education process for end users. LabVantage Sapphire™ Informatics:

  Removes lab bottlenecks to increase research time.
  Uses automated workflows to streamline processes.
  Provides complete traceability throughout the life of each sample element to eliminate concerns of losing track of samples following several platings, re-arrays, or dilutions.
  Tracks samples shared between studies or projects making it virtually impossible to lose track of any selected sample.
  Provides a full-featured, flexible experiment management capability that's applicable in genomics, proteomics, and HTS. This enables rapid automation of experiments and studies, with smart visual objects designing your specific lab's experiments and protocols.
  Integrates with various public and proprietary research databases and search engines through Sapphire™'s web based architecture such as: Blastn, Blastp, Mascot, Medline, SwissProt, PROSITE, dbSNP, and Entrez.
  Maximizes integration of your robotics with seamless perfection.
  The multi-faceted Sapphire™ solution thrives on managing multidimensional arrays. From flexible pattern-specific loading, cherry picking, and re-arraying - to multiple media types including DNA Chips for genomics and IPG Strips - to Gradient gels for proteomics.
  Supports all documentation needs for 21 CFR Part 11 compliance.

About National Cancer Institute. The National Cancer Institute coordinates the National Cancer Program, which conducts and supports research, training, health information dissemination, and other programs with respect to the cause, diagnosis, prevention, and treatment of cancer, rehabilitation from cancer, and the continuing care of cancer patients and the families of cancer patients. Further information about the National Cancer Institute is available at http://www.nci.nih.gov/.

About LabVantage Solutions. A leader in Enterprise LIMS and Life Sciences LIMS solutions, LabVantage Solutions, Inc. is a Chatterjee Management Group company, and an Advanced IBM Business Partner. LabVantage provides intelligent sample and experiment data management LIMS for traditional manufacturing QA/QC, pharmaceutical QC, genomics, proteomics, and high throughput screening. The company also offers services that ensure customer success, such as industry and technology consulting, implementation services, application training, and extensive customer support services. Since 1981, LabVantage has implemented hundreds of laboratory information systems across a broad range of industries. Headquartered in Bridgewater, New Jersey, LabVantage also has offices in High Wycombe, UK, and Kolkata, India, as well as an extensive web of business partnerships and technology alliances. Further information about LabVantage and its products is available at www.labvantage.com.

Certain statements contained in this release may be forward looking statements and are thus prospective. Such forward-looking statements are subject to risks, uncertainties and other factors which could cause actual results to differ materially from future results expressed or implied by such forward looking statements.
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